| Issue date | Song | Artist | UK Singles Chart Peak |
|---|---|---|---|
| January 6 | "Crank That (Soulja Boy)" | Soulja Boy Tell 'Em | 2 |
| January 13 | |||
| January 20 | "Superstar" | Lupe Fiasco feat. Matthew Santos | 4 |
| January 27 | "Don't Stop the Music" | Rihanna | 4 |
| February 3 | "Work" | Kelly Rowland | 4 |
| February 10 | "Don't Stop the Music" | Rihanna | 4 |
| February 17 | |||
| February 24 | |||
| March 2 | |||
| March 9 | "Come On Girl" | Taio Cruz feat. Luciana | 5 |
| March 16 | "Better in Time" | Leona Lewis | 2 |
| March 23 2 | "American Boy"1 | Estelle feat. Kanye West | 1 |
| March 30 2 | |||
| April 6 | "Touch My Body" | Mariah Carey | 5 |
| April 13 2 | "American Boy" | Estelle feat. Kanye West | 1 |
| April 20 | |||
| April 27 | |||
| May 4 | "Wearing My Rolex" | Wiley | 2 |
| May 11 | |||
| May 18 | "Take A Bow"1 | Rihanna | 1 |
| May 25 2 | |||
| June 1 2 | |||
| June 8 | |||
| June 15 | |||
| June 22 | "Closer"1 | Ne-Yo | 1 |
| June 29 2 | |||
| July 6 2 | "Dance wiv Me"1 | Dizzee Rascal feat. Calvin Harris & Chrome | 1 |
| July 13 | "No Air" | Jordin Sparks and Chris Brown | 3 |
| July 20 | |||
| July 27 | |||
| August 3 | |||
| August 10 | |||
| August 17 | |||
| August 24 | "Beggin'" | Madcon | 5 |
| August 31 | "Disturbia" | Rihanna | 3 |
| September 7 | "When I Grow Up" | Pussycat Dolls | 3 |
| September 14 | |||
| September 21 | |||
| September 28 | "Disturbia" | Rihanna | 3 |
| October 5 | "Girls" | Sugababes | 3 |
| October 12 | |||
| October 19 | "Miss Independent" | Ne-Yo | 6 |
| October 26 | "Love Lockdown" | Kanye West | 8 |
| November 2 | |||
| November 9 | |||
| November 16 | "If I Were a Boy"1 | Beyoncé | 1 |
| November 23 2 | |||
| November 30 | "Live Your Life" | T.I. feat. Rihanna | 2 |
| December 7 | |||
| December 14 | |||
| December 21 | "If I Were a Boy" | Beyoncé | 1 |
| December 29 | "Live Your Life" | T.I. feat. Rihanna | 2 |
|
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